20190911 - Transitioning Generalised Read-across (GenRA) towards quantitative predictions (SRA Webinar)

The initial GenRA (baseline) considered structural similarity and/or bioactivity to make binary predictions of toxicity. More recent work has transitioned towards extending the GenRA approach to make quantitative predictions of toxicity and illustrated how the GenRA baseline can be applied in practice. Here we will highlight ongoing research in extending the approach - transitioning to quantitative predictions of points of departure (PODs) with 2 case studies – acute toxicity LD50 values and LOAELs from repeated dose toxicity studies. A GenRA tool has been built in to the EPA CompTox Chemicals Dashboard. The views expressed in this presentation are those of the authors and do not necessarily reflect the views or policies of the U.S. EPA